Depending on your version of Ps, there's usually an easy way and a not so easy way. With that said, if you have CS5 Extended and the hardware to back it up you can always use the 3D tools to do what you want. If you want to isolate a certain portion of an image, photo. whatever you're probably best to use the quick selection tool located underneath the majic wand tool. I have found it to be the best tool to cutting out complex shapes such as a person due to the many lines and curves. Once your done with your selection, cut and paste (Ctrl +X, Ctrl + V for PC, don't know the MAC shortcuts) Now it's anyone's guess which of the 3D tools you might want to use from here on out. But I will say that you can do amazing things with the 3D Repousse tool located in the 3D menu of Photoshop Extended. Attached is the most basic of things that can be done with this option. Imagine what can be done with a little effort.
Sometimes its easy to look at an image and say if it looks 2d or 3d but to describe or put in words exactly why might be a little bit more difficult than that. There can be a number of reasons that make an image look 3d or 2d even though essentially everything you see is on a 2d flat plane called you computer screen. So unless youre talking about stereoscopic or anaglyph images everything is in fact technically 2d. So the only thing we can do is to create the illusion of 3d. Okay so by now i assume you are more confused than what you were before starting this thread?! :P
But seriously lot of factors come into play here. How an object is shaded... how the lighting affects it... Perspective... Relation to other objects in the image... color... etc etc etc... bla bla bla... So once you start adding in these factors, your image will transform from a 2d looking image to a more 3d version. A simple example i just put together quickly below shows how adding shading or shadowing or lighting or whatever you'd like to call it makes a big difference in the following picture:
So in the same way you can try looking into these factors one by one and try applying it to your source image. That way you should get some results.
Here's another comparison of 2 superheroes in case my previous image was too boring for you. :P You can see how its pretty much the same frame but one is way more 3dimensional than the other.