Hi Taz
The steps below will tell you how to get the delta E between the average colors between the two areas.
I am skeptical that this is what you want since you have not described how this single number is going to be used. If you want to know how to convert on average how to convert from one image to the other, delta E will not give you that information. Rather you would want a delta Color Vector. So just a heads up about the delta E number
1) Your image data must be in a known color space e.g. sRGB, Adobe RGB, ProPhoto RGB etc and the image must be color managed in PS (note your images did not have a profile with them)
2) Convert both areas from the know RGB color space to Lab space using Edit > Convert to Profile
2) Independently for each area use the Filter > Blur >Average filter to create the average color over the entire area of each
3) Use eye dropper or color sampler tool and read the Lab values for each.
4) Calculate the root mean square using the two Lab values and you have your delta E
The following formula is specifically for LAB CIE76
Here is the link to the web page with many more details and other delta E models. I just provided you the one most commonly used:
https://en.wikipedia.org/wiki/Color_difference
Hope that helps
John Wheeler