I was asked on the Adobe forum if it was possible to have multiple Guide Sets, and I came up with this script.
This script will only work in Photoshop CS5 or better!
This script will allow you save multiple guide sets.
You can add or remove quide sets.
Guide sets can be appended to existing guides or existing guides can be removed before placing the new set.
The guide set info is held in the documents metadata, so the guide sets travel with the document.
To install the script download the zip file, unzip and you will have GuideSets.jsx
This needs to be placed into Photoshops application folders presets/scripts folder
once this has been done, if Photoshop was open, restart Photoshop so that it can pick the new script.