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Whether it is the paintbrush, marquee, or crop tool - if it requires you to hold down the mouse button and drag on the canvas, it does not work.  I've uninstalled and re-installed to no avail.  I have even downloaded the trail version of cs6, and I still have the same issue.

Sometimes, however, It works when I first open photoshop - though not always - but stops working after I press the ctrl or shift key. 

So, for example, I get a dot if I am trying to paint a line; the marquee and crop tools are useless. 

Please help!  This is driving me insane. 

(I am on a PC using Win7-64bit, problem occurs on both 32 and 64 bit versions of photoshop)