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I am working on a large 2gb tiff panorama.  I have saved it plenty of times before.  After doing some work today, I went to save it and I get an error "Cannot save file because disk is full".  The disk is very much not full.  There was 15gb of free space on the disk when I tried to save (now down to 6gb because each time I try and save it eats up 2gb that it does not release back when the error pops up), and my scratch disk has 60gb of free space as well.  What is going on here?

I don't want to exit out of the program as I've made quite a few changes to the file that I don't want to lose since I can't save.