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Hi Vcize...

There could be a few ways.... but before you give up and close PS.....

Minimize your CS to task bar.....  You need to find and delete the tmp files in Photoshop's TEMP folder or scratch disk. I suspect you have a lot of these from old work or when your PS crashed or even from power fluctuation or outages.

Give that a try.....

You might also want to try saving your work with a different file name....

Or save as a PSB.  If that works, restart PS , open file then try save as a psd or whatever you intended to save it as.    If that doesn't work, at least you have your work safe until you can figure out what the problem is....

One more thing.... What is your cpu and Photoshop version?