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I presume the reason u are asking is because u either lost or discarded the original, or is it because u just don't want to go through all the processing steps at the new rez, right?

Unfortunately, I can think of several different processing schemes that wud accomplish what u described, but would present different challenges, so I can't say with absolute certainty, but my guess is that u won't see much degradation when u up-Rez from 100 to 150 ppi if people view your large print from a reasonable distance, say, over 2 ft away.

T