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Doing a separate up-scaling (aka, up-rez'ing) step in may not produce results all that much better than simply letting your printer driver handle the re-sizing to fill the printed page. 

Before you commit to all that extra work in PS, you should do some experiments where you compare the results with and without the PS up-rez'ing step.

Also, if you really want to see how the very best up-rezing around compares to PS's native tool and your printer driver, you should download a free trial version of BenVista's Photo Zoom Pro v.5, and include it in your tests.  IMHO, it's the best up-rez'er available these days, even better than Genuine Fractals (aka, OnOne Perfect Resize). Photo Zoom Pro features several quite different algorithms, a couple of which are specifically for up-rez'ing graphics (eg, cartoons).

That being said, my guess is that with starting pixel dimensions around 1221 x 1607, and relatively tolerant readers, you probably will decide on just  letting the printer handle the up-rez'ing, but of course, to be sure of this, you really have to do comparative experiments.

Cheers,

Tom