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There is another issue.  Are your cartoons contone (ie,  continuous tone) artwork such as one might get from the original artists, or half-tone (ie, scans of pages mass produced by a large volume offset press)?

If it's the latter, there is a good chance you might see Moire patterns if the line screen frequency is near some multiple or sub multiple of the ppi in your image file.

Why don't you post a small crop from one of your images so we have a better idea what you are dealing with.

Also, I hope your comment about wasting another page on an experiment wasn't serious.  The cost of a few pages for an experiment is utterly insignificant in comparison to a possibly mucked up run of 1000 pages.

Tom