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I just re-read your original post and picked up on the fact that your original is only about the size of a piece of copier paper, ie, ~ 8.5" x 11.5".  Even if there were no half-tone pattern, the resolution used to print the book is not even close to being adequate to have a sharp image when enlarged by 5x (ie, to 5' wide).   The fact that you used a high ppi setting when you scanned it is helpful, but will not produce or improve detail that simply isn't present in the original.

My guess is that if you do nothing to the halftone pattern, most people viewing it will subconsciously catagorize it as a "blow-up" and accept it for what it is. I see this done often with photo-based advertisements (about 5' high) used in the windows of trendy clothing stores in malls.

Tom M