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The quick selection tool will work if there are pixels on that layer to select.....a new blank layer obviously doesn't have any pixels to select.

If you're feeling brave you could...and I stress 'could' flatten all the layers and then the tool will work...but thats a very destructive way to do things.

Instead, use the Ctrl + Alt + Shift + E command I mentioned before, (With the very TOP layer selected), to create a new layer with a 'flattened' version of all the other visible layers in it.....then the tool will work on that new layer.

You can continue to add new layers on top of this one for further 'Healing' or 'Cloning' should you need to but again you'll need to 'flatten' it if you want to select pixels that are not ON the currently active (selected) layer.

Its really just a case of 'building' your layer stack as you go....certain operations require a flattened layer of ALL the pixels, some not....adjustment layers for instance will work on just about any layer regardless.

Regards.

MrToM.