I think Mr Tom, carlbush, and fogo00 all gave good improvements for the image.
I am going to ask/suggest that if you have a better original image that fixes may be improved quite a bit. The provided image is a highly compressed JPEG image. If you have the digital version that is not reduced in pixel dimensions and also not compressed to a smaller size, then we would not have some many JPEG artifacts to deal with that are getting in the way of a better post processing.
To point this out I took your image and extracted out and placed to the right the luminosity, Hue, and Saturation channels of the image in that order. Even the B&W luminosity channel is not very good causing a break in your face (it is not out of focus) and the hue and sat channels are highly compressed as seen by the squares much larger than the pixel sizes.
So it is the JPEG compression that is the #1 limiter for the starting image, not an out of focus shot.
Here is my try taking my que from what others have done and taking out some distractors. Not sure if this is what you want yet I enjoyed the effort. I included the image here and also a link to the full one on Dropbox: